| Core / Architecture | Arm Cortex-M33, single core |
| Clock | Double the Flash (512 KB) and nearly triple the SRAM (256 KB) of the LPC5516 sibling in a larger 100-pin package |
| Memory | 512 KB Flash; 256 KB SRAM |
| Interfaces | Flexcomm USART/SPI/I²C, ADC, timers, GPIO (LPC5500 family peripheral set) |
| Supply Voltage | 1.71 V to 3.6 V |
| Operating Temperature | -40°C to +105°C |
| Security Features | TrustZone supported by the Cortex-M33 core; non-secure LPC5528 variant, does not carry the LPC55S secure-part designation |
| Package Details | 100-HTQFP, 14×14 mm |